In mitochondria, UGA codes for tryptophan rather than stop, AUA for methionine rather than isoleucine, and AGA and AGG are stops rather than arginine. A sequence read by both machineries can therefore give different products. For the MOTS-c frame the difference is decisive: one code gives a full peptide, the other a fragment.
This is a general feature of small open reading frames in mitochondrial DNA, several of which encode mitochondrial-derived peptides.
The authors detected a polyadenylated transcript containing the frame in the cytoplasm, and the peptide itself by antibody in cells and tissue. Mitochondrial ribosomes could not have produced the detected sequence. The conclusion that translation is cytoplasmic rests on this reasoning and on the detection data, and later work has not overturned it.
How the transcript leaves the mitochondrion is not fully resolved.
Because it places MOTS-c in an unusual category: a peptide encoded by one genome and made by the machinery of the other. The page on the mitochondrial-derived peptide family sets out the others.
MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| MOTS-c Pack | 40 mg | AED 950 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
In mitochondria, UGA codes for tryptophan rather than stop, AUA for methionine rather than isoleucine, and AGA and AGG are stops rather than arginine. A sequence read by both machineries can therefore give different products. For the MOTS-c frame the difference is decisive: one code gives a full peptide, the other a fragment.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.