The peptide was engineered from a GIP-based backbone with substitutions that introduced activity at the GLP-1 and glucagon receptors, and carried a fatty-acid side chain to extend its circulating half-life through albumin binding.
The paper reports receptor potency at each of the three targets separately. The result is deliberately unbalanced — potency at the GLP-1 receptor is lower relative to the native hormone than at the other two — which the authors present as a design choice rather than a limitation.
In diet-induced obese mice the compound reduced body weight and food intake and increased energy expenditure, with the glucagon component implicated in the latter. Non-human primate work characterised pharmacokinetics and tolerability.
These are the standard preclinical stages, and they are the evidence on which the first human study was permitted.
It is where the receptor-level characterisation lives. A page describing retatrutide as "a triple agonist" is summarising this paper; the paper itself states the potencies, the assays and the animal models, which is the information a laboratory needs.
It is also the source for the fatty-acid modification and the pharmacokinetic rationale that the later trials rest on.
Retatrutide is supplied by REVIVE LAB UAE as an investigational research material for laboratory use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not approved for any use anywhere, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Retatrutide Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The peptide was engineered from a GIP-based backbone with substitutions that introduced activity at the GLP-1 and glucagon receptors, and carried a fatty-acid side chain to extend its circulating half-life through albumin binding.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.