Receptor potency is determined in cells expressing one receptor type, by measuring the concentration of compound needed to produce a given fraction of maximal signalling — commonly cyclic AMP production for this receptor family. Comparing that against the native hormone gives relative potency.
Doing this separately for each of three receptors is what allows a ratio to be stated at all.
The discovery paper reports retatrutide as a full agonist at all three receptors with GLP-1 receptor potency reduced relative to native GLP-1, while GIP and glucagon receptor potencies were comparatively higher. The authors describe the GLP-1 attenuation as deliberate.
The exact figures are in the paper and depend on the assay system used, which is why a secondary summary should point at the source rather than restate numbers.
A different peptide engaging the same three receptors at a different ratio would be a different pharmacology. Results from one triple agonist do not describe another, and class-level statements about triple agonists are correspondingly weak.
For a researcher, the ratio is also what a receptor assay on a supplied batch would be checked against, were one to be run.
Retatrutide is supplied by REVIVE LAB UAE as an investigational research material for laboratory use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not approved for any use anywhere, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Retatrutide Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Receptor potency is determined in cells expressing one receptor type, by measuring the concentration of compound needed to produce a given fraction of maximal signalling — commonly cyclic AMP production for this receptor family. Comparing that against the native hormone gives relative potency.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.