Structure-activity work after the 1982 isolation showed that successive truncation of the carboxyl terminus left activity intact down to residue 29 and lost it rapidly thereafter. A 29-residue peptide is cheaper to make than a 44-residue one and was the obvious drug candidate. Residues 30 to 44 contribute stability and binding affinity rather than activation.
The acetate salt of the 1-29 amide is the molecule sold as sermorelin to this day in research and compounding contexts.
Approved for children with deficiency on the reasoning that stimulating the pituitary was more physiological than replacing the hormone; in practice recombinant growth hormone was more predictable and sermorelin had a small share. The diagnostic use, provoking a growth hormone pulse to test the pituitary, was its more durable role. Discontinuation in 2008 reflected low sales. It remains approved in no major market as a medicine.
The gap it left is one reason tesamorelin, approved two years later, was received as a new class rather than a successor.
The hexenoyl group on tyrosine 1 defeats the enzyme that inactivates sermorelin and native hormone alike, and retaining residues 30 to 44 restored the affinity the fragment gave up. The result is a molecule with a usable half-life from the same receptor pharmacology.
Tesamorelin is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Tesamorelin Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Structure-activity work after the 1982 isolation showed that successive truncation of the carboxyl terminus left activity intact down to residue 29 and lost it rapidly thereafter. A 29-residue peptide is cheaper to make than a 44-residue one and was the obvious drug candidate. Residues 30 to 44 contribute stability and binding affinity rather than activation.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.