Actin sequestration is stoichiometric: one protein per actin monomer held. A cell with hundreds of micromolar monomeric actin in reserve needs hundreds of micromolar of a sequestering protein, and thymosin beta-4 fills most of that role with profilin filling the rest. The protein is small, unstructured and cheap for the cell to make, which suits a buffer that must be present in bulk. Its expression is highest in motile cells — platelets, leukocytes, migrating cells — which need the largest actin reserve.
The beta-thymosin isoforms share the role in the tissues where they are expressed.
Plasma thymosin beta-4 is in the nanomolar range; wound and blister fluid reach micromolar after cells break and platelets release it. The intracellular pool is a thousandfold above plasma. A fragment or protein added to a tissue from outside meets cells that already contain the protein in abundance, and any extracellular effect must be one the intracellular pool cannot produce because it is on the wrong side of the membrane. That is the logic behind the extracellular-signal hypothesis, and it is also a constraint on it.
The amounts in this pack, in moles, are on their own page.
Because the abundance of the protein is a basic fact that frames the whole fragment literature and is rarely stated. It describes cell biology and no use of the pack.
The BPC-157 + TB500 blend is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for each component of the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| BPC-157 + TB500 Pack | 5 mg + 5 mg | AED 510 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Actin sequestration is stoichiometric: one protein per actin monomer held. A cell with hundreds of micromolar monomeric actin in reserve needs hundreds of micromolar of a sequestering protein, and thymosin beta-4 fills most of that role with profilin filling the rest. The protein is small, unstructured and cheap for the cell to make, which suits a buffer that must be present in bulk. Its expression is highest in motile cells — platelets, leukocytes, migrating cells — which need the largest actin reserve.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.