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The two chemical changes a somatropin lot accumulates, and where

Published 24 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
The main chemical degradation routes of somatropin are deamidation, chiefly at asparagine 149 and asparagine 152 in the third crossover loop, and oxidation of methionine, chiefly at positions 14 and 125 with 170 less exposed. Deamidation converts an asparagine to aspartate or isoaspartate and adds one dalton and a negative charge; oxidation adds sixteen daltons per methionine. Both variants are resolved from the native protein by the pharmacopoeial chromatographic methods and are reported as related proteins.

Deamidation

Asparagine followed by a small flexible residue cyclises to a succinimide that hydrolyses to aspartate or isoaspartate. The reaction is pH and temperature dependent and proceeds in solution far faster than in the dry solid. The deamidated forms are more acidic and separate on ion-exchange or isoelectric focusing.

The 149 and 152 sites were characterised in the 1980s as recombinant material was being developed.

Oxidation

Methionine sulfur reacts with dissolved oxygen, peroxides or light-generated species to the sulfoxide. Met14 and Met125 are surface-exposed; Met170 is partly buried. Oxidised forms are slightly more polar and resolve on reversed-phase chromatography.

Protect-from-light storage addresses one driver of this reaction.

Detection and limits

Pharmacopoeial monographs for somatropin specify reversed-phase and size-exclusion methods and set limits on related proteins and dimers. A certificate for research material reports what the batch showed under stated methods.

Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
HGH Somatropin Pack24 mg (72 IU)AED 850In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

Deamidation?

Asparagine followed by a small flexible residue cyclises to a succinimide that hydrolyses to aspartate or isoaspartate. The reaction is pH and temperature dependent and proceeds in solution far faster than in the dry solid. The deamidated forms are more acidic and separate on ion-exchange or isoelectric focusing.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

HGH Somatropin Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

→ HGH Somatropin Pack — 24 mg (72 IU) → Reversed-phase HPLC of a protein → Aggregation: the real failure mode

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.