The receptor was purified from rabbit liver, sequenced, and its complementary DNA cloned from rabbit and human. The serum binding protein, known since the 1960s, matched the extracellular domain exactly. In humans it is generated by a metalloprotease cutting the receptor near the membrane; in rodents by alternative splicing. The same paper placed the receptor in what became the class I cytokine receptor family.
This was the first member of that family to be cloned.
Bound hormone is cleared more slowly and cannot bind cell-surface receptors, so the binding protein acts as a buffer: it smooths the pulsatile signal and holds a reserve. Its level is low in Laron syndrome, where the receptor is absent or truncated, and is used as a marker of receptor status. It also complicates measurement, since immunoassays differ in whether they see bound hormone.
The crystal structure of hormone bound to this domain is the 1992 structure described elsewhere.
The recombinant hormone in the pack is the ligand this protein binds, and the binding protein is part of the established pharmacology of the hormone in circulation. It is physiology, stated as such.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The receptor was purified from rabbit liver, sequenced, and its complementary DNA cloned from rabbit and human. The serum binding protein, known since the 1960s, matched the extracellular domain exactly. In humans it is generated by a metalloprotease cutting the receptor near the membrane; in rodents by alternative splicing. The same paper placed the receptor in what became the class I cytokine receptor family.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.