Exon 2 encodes the signal peptide and the first residues; exons 3 to 7 the extracellular domain; exon 8 the membrane segment; exons 9 and 10 the cytoplasmic domain. Promoter regions upstream give tissue-specific expression, highest in liver. Inactivating mutations throughout cause Laron syndrome, with over seventy described.
The cytoplasmic tail carries the sites that recruit JAK2 and dock STAT5.
A retroviral insertion event in the primate lineage made exon 3 skippable, and in humans two alleles — full-length and deleted — circulate at roughly equal frequency. The deleted receptor binds hormone normally and signals somewhat more strongly in cell assays. The 2004 report found carriers grew faster on treatment; meta-analyses since find a small effect on average with much variation between studies.
It is one of the most studied pharmacogenetic variants in endocrinology, and the evidence remains mixed.
Anything about any use of the material in the pack. It describes the gene for the receptor the hormone acts on, and one of its variants, as the literature reports them.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Exon 2 encodes the signal peptide and the first residues; exons 3 to 7 the extracellular domain; exon 8 the membrane segment; exons 9 and 10 the cytoplasmic domain. Promoter regions upstream give tissue-specific expression, highest in liver. Inactivating mutations throughout cause Laron syndrome, with over seventy described.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.