The alanine-scanning and crystal-structure work of 1989 to 1992 located the two receptor-binding sites and identified glycine 120 as a residue at site 2 whose replacement with a bulky side chain prevented the second receptor from binding. Phage display then selected site 1 mutations that increased affinity. The engineered protein, called B2036 before pegylation, bound the receptor better than the natural hormone and did nothing.
Pegylation lowered its affinity somewhat but extended its circulation from minutes to days.
In 112 patients with acromegaly, IGF-1 fell into the normal range in the great majority of those receiving the active drug over twelve weeks, with symptom improvement. Growth hormone itself rose, because the feedback that normally restrains it was blocked, which is why treatment is monitored by IGF-1 rather than growth hormone.
It remains the only growth hormone receptor antagonist in clinical use.
That receptor activation requires both sites and that blocking one is enough to abolish signalling in vivo. It is pharmacology of the receptor, stated here because the receptor is what the hormone in the pack acts on.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The alanine-scanning and crystal-structure work of 1989 to 1992 located the two receptor-binding sites and identified glycine 120 as a residue at site 2 whose replacement with a bulky side chain prevented the second receptor from binding. Phage display then selected site 1 mutations that increased affinity. The engineered protein, called B2036 before pegylation, bound the receptor better than the natural hormone and did nothing.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.