The resting receptor holds its two halves apart in an inverted V, stabilised by contacts that keep the kinases separated. IGF-1 inserts at the apex, bridging elements from both halves. The receptor collapses inward and the legs come together. The ligand sits in a site composed of both protomers, which is why it is a dimer-spanning interaction rather than two independent sites.
Comparable structures of the insulin receptor showed a related but distinct mode with up to four insulins bound.
That one IGF-1 is sufficient to activate the receptor; that the alpha-chain carboxyl-terminal segment is a true part of the binding site; and that activation is a large-scale rearrangement rather than a subtle local change. These had been inferred biochemically for decades and were now visible.
The structures also showed where IGF-1 LR3 would differ: the extension sits at the amino terminus, away from the receptor contacts, consistent with its modest effect on receptor affinity.
The receptor is what the molecule in the pack acts on, and the structures are the current picture of that interaction. This page describes them.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The resting receptor holds its two halves apart in an inverted V, stabilised by contacts that keep the kinases separated. IGF-1 inserts at the apex, bridging elements from both halves. The receptor collapses inward and the legs come together. The ligand sits in a site composed of both protomers, which is why it is a dimer-spanning interaction rather than two independent sites.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.