Mitochondrial open reading frame of the twelve S ribosomal RNA, type c

Published 26 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
MOTS-c stands for Mitochondrial Open reading frame of the Twelve S ribosomal RNA, type-c. The name records its genomic address rather than any function: an open reading frame — a stretch of DNA that could encode a peptide — found within the mitochondrial gene for the 12S ribosomal RNA. The suffix c distinguishes the frame from other candidate frames the 2015 authors examined in the same gene. Humanin and the SHLPs, from the 16S gene, were named differently, by function and by resemblance.

Each part

Mitochondrial: encoded by mitochondrial, not nuclear, DNA. Open reading frame: a sequence with a start codon and no internal stop, in the frame read, long enough to be a candidate gene. Twelve S: the smaller of the two mitochondrial ribosomal RNAs, named for its sedimentation coefficient. Type-c: the designation given to this frame among several screened.

The 12S gene is better known as the site of mutations causing aminoglycoside-induced deafness.

Why the address, not the function

When the peptide was found, its function was being established in the same paper. Naming by location is neutral and permanent, where naming by function can age badly. Humanin was named for the hope attached to it in 2001; MOTS-c was named for where it lives.

Later literature sometimes refers to it as a mitochondrial-derived peptide or MDP, the class name.

On the product page

The catalogue lists the peptide under its established name and describes it as a mitochondrial-derived peptide of 16 amino acids. The name tells a reader where to look in the genome; the pages here tell them what was found.

MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
MOTS-c Pack40 mgAED 950In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

Each part?

Mitochondrial: encoded by mitochondrial, not nuclear, DNA. Open reading frame: a sequence with a start codon and no internal stop, in the frame read, long enough to be a candidate gene. Twelve S: the smaller of the two mitochondrial ribosomal RNAs, named for its sedimentation coefficient. Type-c: the designation given to this frame among several screened.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

MOTS-c Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.