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Who Discovered GHK-Cu?

Published 2026-10-26 · REVIVE Peptides Research Desk · 1 min read
Short answer: Loren Pickart, then a biochemist at the University of California, San Francisco, isolated the tripeptide glycyl-L-histidyl-L-lysine from human plasma in 1973 while studying why plasma from young donors affected liver tissue differently from plasma from older donors. The copper complex, GHK-Cu, and its affinity for copper were characterised in the years that followed, and Pickart published on the peptide for the next five decades.

The discovery paper appeared in Nature New Biology in 1973. Pickart went on to found companies that put GHK-Cu into cosmetics, which is why much of the later literature carries his name and should be read with that in mind.

Independent groups — Maquart and colleagues in France among them — reported on the peptide in the 1980s and 1990s, and those papers are cited on their own pages.

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