Dipeptidyl peptidase 4, also known as CD26, is expressed on endothelium, kidney, intestine and lymphocytes and circulates in soluble form. It is a serine protease with strict specificity for a proline or alanine at position 2 and a free amino terminus. Many peptide hormones fit — GLP-1, GIP, GHRH, substance P, several chemokines — which is why the enzyme is a drug target in its own right for diabetes.
Inhibitors of the enzyme, the gliptins, raise native GLP-1 and also, incidentally, native GHRH.
GHRH 3-44 retains most of the sequence but lacks the tyrosine that the receptor requires, so it is not just weaker but inactive, and it may occupy the receptor without signalling. Blocking the amino terminus with any acyl group prevents enzyme binding; the hexenoyl group was chosen as the smallest that gave full protection while preserving receptor affinity. The half-life extension is about tenfold, enough for a practical pharmacology, not enough for a long-acting profile.
CJC-1295, a different analogue, adds amino acid substitutions and an albumin-binding group to go further.
Because the one modification that defines tesamorelin exists to defeat this enzyme, and the half-life is part of the established pharmacology. It describes chemistry and no use of the pack.
Tesamorelin is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Tesamorelin Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Dipeptidyl peptidase 4, also known as CD26, is expressed on endothelium, kidney, intestine and lymphocytes and circulates in soluble form. It is a serine protease with strict specificity for a proline or alanine at position 2 and a free amino terminus. Many peptide hormones fit — GLP-1, GIP, GHRH, substance P, several chemokines — which is why the enzyme is a drug target in its own right for diabetes.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.