Proton spectroscopy, the fat fraction, and the biopsies behind the 2019 trial

Published 26 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Stanley and colleagues measured liver fat in 2014 by proton magnetic resonance spectroscopy, which reads the fraction of the liver signal coming from fat in a voxel placed in the right lobe; a fraction above about 5 per cent defines fatty liver. In the 2019 trial in the Lancet HIV, participants also underwent liver biopsy at entry and at twelve months, scored by pathologists for steatosis, inflammation, ballooning and fibrosis. Hepatic fat fraction fell in the tesamorelin groups relative to placebo in both trials, and in 2019 fewer treated participants progressed in fibrosis. Both measurements are the standard tools of liver trials and each has limits.

Spectroscopy

A magnetic resonance scanner records the signal from a small volume of liver and separates the water and fat peaks; their ratio is the fat fraction. It is non-invasive, precise and sensitive to small changes, and it is the usual primary endpoint for early-phase liver fat trials. It measures fat only — not inflammation, not fibrosis — and samples one region of a large organ.

Whole-liver proton density fat fraction imaging extends the same principle across the organ.

Biopsy

A needle core read under the microscope, scored for the components of fatty liver disease and staged for fibrosis. It is the reference standard and the only method that sees inflammation and scarring directly, and it is invasive, samples a tiny fraction of the liver, and varies between readers. Trials pair a baseline and a follow-up biopsy and report change in score, which the 2019 trial did.

The fibrosis finding in 2019 — less progression in the treated group — was a secondary endpoint in a trial of about sixty people and is reported here with that weight.

Why it is here

Because the liver findings are among the most cited for tesamorelin and depend on two methods a reader should understand. It describes methods and no use of the pack.

Tesamorelin is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
Tesamorelin Pack20 mgAED 1010In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

Spectroscopy?

A magnetic resonance scanner records the signal from a small volume of liver and separates the water and fat peaks; their ratio is the fat fraction. It is non-invasive, precise and sensitive to small changes, and it is the usual primary endpoint for early-phase liver fat trials. It measures fat only — not inflammation, not fibrosis — and samples one region of a large organ.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

Tesamorelin Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.