Des(1-3)IGF-1, a naturally occurring truncated form first isolated from brain and later from colostrum, binds the binding proteins up to a hundredfold less well than full-length IGF-1 and is correspondingly more potent in culture. Residue 3 was implicated as the critical one. A substitution that disrupted its contribution without removing residues 1 and 2 gave a molecule that kept the full chain.
The design was rational, built on the truncated natural variant.
The binding-protein surface that meets the IGF-1 amino terminus carries basic residues complementary to glutamate 3. An arginine there repels rather than attracts. Combined with the 13-residue extension, which sterically blocks the same region, the result is a binding-protein affinity reduced by orders of magnitude.
Receptor binding falls only modestly, because the receptor contacts the B domain helix and the A domain, not residue 3.
The substitution is part of the expected mass and is confirmed by intact mass and, where run, by peptide mapping of the amino-terminal fragment. A molecule with glutamate at 3 would be a different product.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Des(1-3)IGF-1, a naturally occurring truncated form first isolated from brain and later from colostrum, binds the binding proteins up to a hundredfold less well than full-length IGF-1 and is correspondingly more potent in culture. Residue 3 was implicated as the critical one. A substitution that disrupted its contribution without removing residues 1 and 2 gave a molecule that kept the full chain.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.