What was measured in people, what was done in mice of three ages, and what each part can and cannot support

Published 26 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
The 2021 paper has two parts. In the human part, sedentary young men performed a bout of cycling exercise and gave muscle biopsies and blood before, during and after; MOTS-c rose in muscle during exercise and in plasma afterwards, returning toward baseline within hours. In the mouse part, young, middle-aged and old mice were given the human peptide and run on treadmills; treated animals of every age ran longer, and old treated animals showed improved gait, grip and other measures compared with untreated old mice. The human arm shows the endogenous peptide responds to exercise; the mouse arm shows the administered peptide affects performance in mice. Neither shows what administration does in people.

The human arm

Ten young men, a single exercise session, serial biopsies of the thigh muscle and serial blood samples. MOTS-c in muscle increased several-fold during the bout and plasma MOTS-c rose after it. The study also reported MOTS-c protein and transcript responses and related them to the metabolic changes of exercise. It is an observation of an endogenous response and is the first human muscle data on the peptide.

Small, male, young, one bout; no women, no older adults, no training programme.

The mouse arm

Mice at roughly two, twelve and twenty-two months were treated for several weeks and tested on a treadmill to exhaustion and in other functional assays. Treated mice ran further at every age, and the oldest treated mice were compared with untreated middle-aged mice on some measures. A separate group on a high-fat diet showed metabolic improvement. Muscle gene expression analyses accompanied the functional data.

The peptide used was the human sequence, which differs from the mouse one.

The boundary

The paper shows that MOTS-c is exercise-responsive in people and that giving it changes exercise performance in mice. It does not show that giving it to people does anything, and it does not test that. The pack is a research material and this page describes a study.

MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
MOTS-c Pack40 mgAED 950In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

The human arm?

Ten young men, a single exercise session, serial biopsies of the thigh muscle and serial blood samples. MOTS-c in muscle increased several-fold during the bout and plasma MOTS-c rose after it. The study also reported MOTS-c protein and transcript responses and related them to the metabolic changes of exercise. It is an observation of an endogenous response and is the first human muscle data on the peptide.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

MOTS-c Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

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Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.