The tumours are rare and the diagnosis is made by measuring GHRH in blood, which is undetectable in pituitary acromegaly and high in the ectopic form. Pituitary imaging shows a uniformly enlarged gland rather than a discrete adenoma, and histology shows hyperplasia. The condition is a natural experiment in continuous rather than pulsatile releasing-hormone exposure: the pituitary does not desensitise, and growth hormone excess is sustained.
It is the clinical counterpart of the giant mice that overexpress the hormone.
Somatotroph adenomas express the GHRH receptor and respond to the hormone, which is why it was once used to test them. The gsp mutation replaces a residue needed to switch Gs alpha off, so cyclic AMP stays high as if the receptor were permanently occupied. The mutation was among the first oncogenes identified in an endocrine tumour, in 1989, and it ties the receptor signal directly to proliferation of the cell.
This is the basis of the active-malignancy and pituitary-tumour exclusions on the tesamorelin label.
Because the pathology of excess signalling is part of what is established about the receptor the molecule acts on. It describes disease biology and no use of the pack.
Tesamorelin is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Tesamorelin Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The tumours are rare and the diagnosis is made by measuring GHRH in blood, which is undetectable in pituitary acromegaly and high in the ectopic form. Pituitary imaging shows a uniformly enlarged gland rather than a discrete adenoma, and histology shows hyperplasia. The condition is a natural experiment in continuous rather than pulsatile releasing-hormone exposure: the pituitary does not desensitise, and growth hormone excess is sustained.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.